anticonvulsants medication

Research Papers

EEG biofeedback and relaxation training in the control of epileptic seizures

Tozzo, Carmen A., Elfner, Lloyd F., May Jr., Jack G. (1988) · International Journal of Psychophysiology

Research utilizing sensorimotor rhythm (SMR) biofeedback with epileptics suggests that it is useful in decreasing seizures. Subjects were 6 young adults with a diagnosis of epilepsy of at least two years who had been unable to control their seizures with different regimens of anticonvulsant medications. Subjects ranged from severely mentally handicapped to above average functioning. Seizure type, frequency, and duration were recorded by subjects and caretakers. Measures of operant learning were percent time in SMR. The experiment utilized a single subject multiple baseline design which consisted of 6 phases: baseline one, relaxation training; baseline two, biofeedback training one; baseline three, biofeedback treatment two and follow-up. The results of this study are in agreement with other studies using SMR biofeedback. All subjects were able to significantly increase percent time in SMR. Five out of the 6 subjects demonstrated decreases in seizure frequency during the treatment phase. Two of the 6 subjects benefited from relaxation training. Four subjects demonstrated significant negative correlations between percent SMR and seizure rates. Consistent with other studies utilizing multiple baseline designs, a majority of the subjects did not follow the design of the study.

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Operant conditioning of the EEG in two patients with epilepsy: Methodologic and clinical considerations

Finley, William W. (1977) · The Pavlovian Journal of Biological Science : Official Journal of the Pavlovian

Methodologic and clinical considerations are discussed in sensorimotor rhythm (SMR) biofeedback research on two dissimilar but severe epileptic males. The first case, an akinetic epileptic who prior to feedback training experienced 80–100 clinical seizures every 10 hours, showed considerable seizure reduction after 6 months of SMR and epileptiform training. A number of methodologic and instrumentation advances were pioneered with the akinetic patient: (1) development of and ultra-sharp band-pass filter; (2) use of epileptiform inhibit and feed-back circuitry; (3) use of monetary rewards as additional incentive; (4) use of correlational analysis for evaluation of acquisition in the major dependent variables and; (5) use of noncontingent feedback and rein-forcement as control techniques. The second case, a psychomotor epileptic, also showed therapeutic benefit from SMR training. Clinical information regarding the effect of anticonvulsant medications on the course and therapeutic outcome of SMR training are described. In conjunction with operant conditioning of 12 Hz activity, corresponding changes for other EEG parameters are examined.

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