EEG phenotypes

EEG PHENOTYPES PREDICT TREATMENT OUTCOME TO STIMULANTS IN CHILDREN WITH ADHD

This study demonstrates that the EEG Phenotypes as described by Johnstone, Gunkelman & Lunt [19] are clearly identifiable EEG patterns with good inter-rater reliability. Furthermore, it was also demonstrated that these EEG phenotypes occurred in both ADHD subjects as well as healthy control subjects. The Frontal Slow, the Slow Alpha Peak Frequency and the Low Voltage EEG Phenotype seemed to discriminate ADHD subjects best from the control group, however not significantly. The Frontal Slow group responded to a stimulant with a clinically relevant decreased number of false negative errors on the CPT. The Frontal Slow and Slowed Alpha Peak Frequency phenotypes, have very different etiologies as evidenced by the treatment response to stimulants. In previous research the slowed alpha peak frequency has most likely erroneously shown up as a Frontal Theta sub-group. This implies that future research employing EEG measures in ADHD should avoid using traditional frequency bands, but clearly dissociate slowed alpha peak frequency from frontal theta by taking the individual alpha peak frequency into account. Furthermore, the divergence from normal of the frequency bands pertaining to the various phenotypes is greater in the clinical group than in the controls. Investigating EEG Phenotypes seems to be a promising new way to approach EEG data, explaining much of the variance in EEG’s, and thereby potentially leading to more specific prospective treatment outcomes.